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First Two-Year Clinical Data For
Reductil Slimming Pills Demonstrates
Efficacy in Helping Overweight People Maintain Long-Term* Weight Loss.
PR Newswire
June 4, 2008
Growing the Market for Anti-Obesity Drugs
Chemical Marketer Reporter
July 15, 2008
Reductil Evaluated for Weight Maintenance
Psychopharmacology Update
October, 2008
Missing Link Can Help
Europeans Control Their Weight
PR Newswire
July 17, 2008
Prescription Appetite Suppressants Bring New Hope to Dieters
Drug Store News
September 12, 2008
First Two-Year
Clinical Data For Reductil Demonstrates Efficacy in Helping
Overweight People Maintain Long-Term*
Weight Loss.
PR Newswire
June 4, 2008
Results
from the second phase of the STORM study -- Reductil Trial
in Obesity Reduction
and Maintenance
--
released today
at the European Congress on Obesity in Milan
suggest that Reductil slimming pills are effective
in helping most people maintain initial six month
weight loss for
up to two years. According to the study, 87 percent
of people taking Reductil maintained more than
a
eighty percent
weight
loss (compared
to 10 percent in placebo (sugar pill) group) and
87 percent
maintained more than a ninety percent weight loss
(compared to 11
percent in the
placebo group).
"There
was a significant difference between the Reductil and a placebo
in the STORM study that has important
clinical benefits," remarked
Arne Astrup, M.D., Ph.D., STORM investigator
and professor of human nutrition at the Royal Veterinary and Agricultural University
of
Denmark.
For many people,
maintaining weight loss is a difficult task. According to Kelly
Brownell,
Ph.D., director
of the Yale
Center for Eating
and Weight Disorders at Yale University in
New
Haven, Conn., "Maintenance
is essential for realizing the health and
psychological benefits of initial weight
loss. Without the
right tools, regain of lost
weight can be an all too common experience."
 Reductil
works by affecting chemicals in the brain
involved in regulating appetite and
helps people
overcome one
of the biggest barriers
to losing weight, because it helps them
feel full so they can eat less -- a feeling also
known as
satiety.
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Clinical
studies with Reductil have shown
Reductil to be a well tolerated,
safe and effective
weight
management
medication
with the majority
of people losing between twenty and
thirty percent of their body weight.
Early
findings from
the
STORM
study
appear
to reconfirm
previous
studies showing weight loss and
maintenance of weight loss.
Professor Astrup
added, "These
interim STORM results show that these Reductil slimming pills
are much more effective than we
had hoped."
About Reductil Slimming Pills
Reductil is
indicated for the management of overweight individuals, including
weight loss
and maintenance of
weight loss when used
in conjunction with
a reduced-calorie diet.
Reductil is recommended
for patients
with an
initial BMI (body
mass
index --
weight in kilograms
divided
by height in meters
squared) greater than or equal
to 30 kg/m(squared) or greater
than or
equal to
27 kg/m(squared)
in the presence
of other risk factors
(e.g., hypertension,
diabetes, dyslipidemia).
Reductil is taken once
a day without regard to meals.
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Growing
the Market
for
Anti-Obesity
Drugs
Chemical
Marketer
Reporter
July 15, 2008
The
anti-obesity
drug
market
has
seen
a
major upswing
in
growth
during
the
past
year
as
new
drugs
entered
the
marketplace,
offering
fresh
alternatives
for
drug-assisted
weight
loss.
With
the
introduction
of
Knoll's
Reductil
(sibutramine)
in
1998
and
the
more
recent
approval
of
Roche's
Xenical
(orlistat)
in
April
1999,
the
market
has
grown
70
percent
in
just
one
year.
However
the entry
of Reductil
and Xenical
may turn
this around.
The US
market for
prescription anti-obesity
drugs tallied
$321 million
in 1999,
according to
IMS Health.
While representing
a small
portion of
the overall
drug market,
this segment
has grown
substantially over
the previous
year where
the market
was reported
at $188
million. The
dramatic shift
can be
attributed to
the introduction
of two
new drugs--Roche's Xenical and
Meridia, made
by the
Knoll Pharmaceuticals,
the pharmaceutical
unit of
BASF.
Competing
directly with
Xenical in
the diet
drug market
is Knoll's
Reductil. Reductil,
a reuptake
inhibitor functions
on the
brain to
control hunger
by inhibiting
the reuptake
of the
neurotrausmitter norepinephrine
and
seratonin. Reductil
functions differently
than the
diet drug
phentermine, which,
besides preventing
the reuptake
of seratonin,
acts to
increase the
release of
seratonin into
the brain,
explains a
Knoll official.
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Reductil sales exceeded
$125 million,
according to IMS Health.T One
of the
keys to
market penetration
in the
anti-obesity drug
market is
to build
consumer awareness
of the
need for
such drugs.
Currently only
10 percent
of the
population considered
at health
risk due
to obesity
are on
prescription treatment. "The challenge
is to get the information out to the public," the BASF official. "By
advertising through television and magazines, patients are learning
about these drug options first hand and are going to their physicians,
requesting medication for obesity, rather than relying on the
physician to broach what could be a delicate topic." Knoll
Pharmaceutical was the first to use direct-to-consumer marketing
for Reductil.
Health
care providers
too are
beginning to
realize the
need for
drug treatment
to help
combat obesity,
Last year,
only 30
percent of
healthcare providers
covered prescription
drugs for
obesity, but
there are
now at
least 36
percent that
do so.
In the
past obesity
was considered
a social
issue, related
to a
lack of
willpower and
exercise. More
and more,
obesity is
being recognizing
as a
serious, life-threatening
disease. Some
observers even
term obesity
an epidemic.
Reductil remains one of the most promising
slimming pills available in Europe. Numerous clinical trials
continue to show that individuals lose 2-3 times more weight when
they combine Reductil in their healthy diet plan.
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Reductil
Evaluated for Weight Maintenance
Psychopharmacology Update
October, 2008
Investigators
conducted a randomized, double-blind trial to assess the usefulness
of Reductil in maintaining
substantial
weight loss over two years.
Eight European
centers recruited 2605 obese patients Patients
received 15 mg of Reductil for six months and followed an individualized 600
calorie-per-day deficit program based on their resting metabolic
rates. Then, 87%
of patients with more than a 5 percent weight loss were randomly
assigned to received 15mg daily of Reductil (or placebo
(sugar pill) for 18 months further. The dose of Reductil was increased
up to 20 mg daily if weight regain occurred.
The primary
outcome measure of the study was the number of patients at year
two who
had maintained at least 90 percent of the weight loss between
baseline and month six.
Of patients on Reductil who completed the study,
83%
maintained 90 percent or more of their original weight loss
compared with 16% of the patients in the placebo group (sugar pill).
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In addition,
patients had substantial decreases in triglyceride, cholesterol,
insulin, uric acid and other levels,
which were sustained
in the Reductil group but not the placebo group.
The individualized management program achieved weight loss in
87
percent of over weight patients sustained weight loss in most patients
continuing therapy for two years," Therefore Reductil is
very helpful in allowing individuals to lose their initial weight
and to keep the weight off, the authors concluded.
Reductil Weight Loss
Conclusion,
Reductil significantly promoted earl weight loss in the treatment
and then more importantly some 87 percent of individuals kept the
weight that they initially lost for up to 2 full years. This is such
promising news for those individuals trying to lose weight.
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Missing Link
Can Help European Control Their Weight
PR Newswire
July 17, 2007Experts Convene
to Discuss New Survey Results, Importance of Brain and Stomach
Connection When It Comes to Eating and the
Role of
Medication in Facilitating This Connection Europeans do not clearly understand the
essential role that satiety -- feeling full when eating -- plays in
weight management, according to national experts who convened in New
York City to analyze results from a nationwide survey, the Weight
Expectations Report. These experts in the behavioral and clinical
practice of weight management concluded that learning to recognize
and respond to feelings of fullness, or satiety cues, is a missing
link in enabling people to control their weight. "One of the most interesting findings from
this survey is the link between satiety, control of one's weight and
the feeling of control over one's life. If we can use satiety to
help people understand how to gain control of their food intake and
ultimately their weight, the repercussions for health -- both
physical and emotional -- are significant," said Kelly Brownell,
Ph.D., director of the Yale University Center for Eating and Weight
Disorders, New Haven, Conn. and moderator of the roundtable. "Our society is bombarded with an over
abundant supply of high-calorie, high fat foods which makes the
enhancement of satiety that much more important," added Dr.
Brownell.
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Key Finding to Weight Loss:
Satiety, Control and Self-Image According to
the report, only 25 percent of Europeans achieve satiety "all
of the time" when they eat, 44 percent achieve it "some
of the time" and nearly three out of 10 "hardly ever" achieve
satiety. Moreover, nearly half (47%) of people who experience feelings
of fullness continue eating, overriding their "little voice" known
as satiety. Respondents
who "hardly ever" experience
satiety, and continue to eat after feeling full, believed they
had much more
weight to lose than those that consistently responded to feelings
of fullness (27 pounds versus 13 pounds). Conversely, people who
were able to control their weight had a more positive self-image.
On average, men had a more positive self-image than women.
Specifically,
at least three out of five respondents who described themselves
as being in control of their weight see themselves as:
- Self-motivated
in attaining financial security 81%
Possessing high self-esteem 81%
Possessing
a positive body image 80%
Self-motivated
in a career path 76%
- Self-motivated
in a physical exercise program 60%
Key Finding:
Satisfaction with Weight Loss Strategy Teaching people
how to relearn satiety is a key strategy in a successful weight-management
program, but one of the most difficult to implement.
Weight loss strategies vary and can include increasing physical
activity, reducing calorie intake, eating smaller portions, taking
prescription weight-loss medication, as well as restricting fats,
sugar or carbohydrates from the diet.
"All too often, Europeans are looking for a quick fix, like eliminating
fats or carbohydrates completely from their diet. People need to
learn that eating a variety of portion-controlled foods without
eliminating any one dietary component is the way to support healthy
weight goals and live a 'real' life," emphasized Cathy Nonas,
M.S., R.D., a registered dietician at the Theodore B. Van Itallie
Center for Nutrition and Weight Management at St. Lukes-Roosevelt
Hospital in New York, N.Y., and a participant in the roundtable. *
In the past
year, four-fifths (80%) of Europeans said they tried at least
one weight loss strategy. People who used at least one
strategy tried an average of four strategies during that time
period. Key Finding: Role of Reductil Slimming
Pills in Satiety "Some of my patients do not receive the 'I feel full' message. In
such instances, I feel it is helpful to them to prescribe medication
that affects the appetite control center in the brain to help them
reestablish that connection," noted Peter Vash, M.D., assistant
professor at UCLA Medical Center iwho regularly
counsels patients on weight management and a roundtable contributor.
According to
Maria Jenkins, a person taking Reductil and a roundtable participant, "I tried eliminating fats from my diet but I
still wasn't reducing the amount of food I ate so I was not losing
weight. With the help of Reductil, I am able to recognize when
I feel full and eat less. Feeling satisfied with less food has
helped me regain control of my weight and my life."
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Ms. Nonas
added that, "Learning to eat less and listening
to your 'little voice' in an environment that tells us to eat more
is not easy. A low-calorie diet and increased physical activity,
and in some cases medication, are an essential part of that learning
process for my patients." Dr. Vash confirmed
that, "With
Reductil, my patients now have a safe, effective and well tolerated
option to help them gain control
over their eating habits. However, no medication is a magic bullet
for weight loss -- my patients understand they have to do their
part with diet and exercise."
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Prescription Appetite Suppressants Bring New Hope to Dieters
Drug Store News
September12, 2007Obesity is
a serious medical condition with high health risks, contributing
to a myriad
of other health problems, such as atherosclerosis,
hypertension, coronary heart disease, dyslipidemias and diabetes
mellitus, to name only a few. Weight loss of only a few pounds
can significantly reduce the health risks associated with any
such disease state to improve both the prognosis and quality
of life
for successful patients. Reductilt represent what is considered to be some real progress
toward developing appetite
suppressants that are
actually safe and effective. Their mechanisms of action differ
markedly from their marketed predecessors. Reductil Slimming PillsRather than
increase production of serotonin like Redux, Reductil
is a monoamine
repute inhibitor that effectively increases levels of both serotonin
and noradrenaline by retarding their normal removal from the
sites of action. . The higher levels of these neurotransmitters have been
shown to both increase metabolic rate and reduce appetite, a
very
effective combination for weight reduction, especially in conjunction
with a carefully managed program of exercise, diet and behavior
modification.
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Reductil
has little effect on monoamine oxidase but blocks reuptake of
dopamine to some extent, in addition to
its effects on serotonin
and noradrenaline. Available in 5-mg, 10-mg and 15-mg capsules,
initial recommended dose is 15 mg daily without regard to meals,
with an increase to 15 mg daily for unresponsive patients.
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